Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 20, Issue 2, Pages 203-206Publisher
HUMANA PRESS INC
DOI: 10.1385/JMN:20:2:203
Keywords
amyloid; plaques; tangles; tau; genetic; Alzheimer's disease; Pick's disease
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Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.
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