Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 132, Issue 1, Pages 137-143Publisher
WILEY
DOI: 10.1046/j.1365-2249.2003.02114.x
Keywords
ELIspot; herpesvirus; HLA; lymphocytes; peptides
Categories
Ask authors/readers for more resources
An increased frequency of antiviral CD8(+) T cells is seen in chronic viral infections. During herpes virus infections the expanded CD8(+) T cells are thought to control the reactivation of the latent infection. Because multiple sclerosis (MS), a presumed autoimmune disease of the central nervous system, has been associated with a late Epstein-Barr virus (EBV) infection, we wished to examine whether the CD8(+) T cell response to EBV epitopes differed between MS patients and healthy controls. Here we report an increased frequency of CD8(+) T cells responding to EBV epitopes from nuclear antigen 3 A (HLA-A2/CLG) and latent membrane protein 2 (HLA-B7/RPP) in MS patients. Noticeably, the altered CD8(+) T cell response occurred to some but not all EBV epitopes and did not reach the high level seen during acute infection. The responses towards two immunodominant epitopes from human cytomegalovirus (HCMV) were similar in MS patients and normal controls. Together, our data demonstrate the presence of an increased frequency of CD8(+) T cells reacting with two epitopes from EBV in patients with MS. The altered response to only two of the tested EBV epitopes would be consistent with the presence of cross-reactive epitopes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available