Journal
GYNECOLOGIC ONCOLOGY
Volume 89, Issue 1, Pages 95-98Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0090-8258(03)00007-6
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Funding
- NCI NIH HHS [CA27469, CA37517] Funding Source: Medline
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Objectives. To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. Methods. Patients received dolastatim-10 400 mug/m(2) intravenously every 3 weeks and tumor measurements were performed every one to two cycles. Results. Of 28 patients evaluable for response, there were no complete or partial responses. Seven patients had stable disease and 21 patients had increasing disease. Conclusions. Dolastatin-10 has minimal activity in recurrent platinum-sensitive ovarian carcinoma at the dose and schedule tested. (C) 2003 Elsevier Science (USA). All rights reserved.
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