Antibacterial activities of a few prepared derivatives of oleanolic acid and of other natural triterpenic compounds

Oxidizing. phosphorus, ester and amide derivatives of oleanolic acid 1 have been prepared. The antibacterial activity of compound 1, isolated from the fruit barks of Periploca laevigata (Asclepiadaceae), and its derivatives have been tested using Tween-80 as complex agent to form a water-soluble triterpenes. The same activity of maslinic acid acetate 2, beta-amyrin 3, and its acetylated derivative 3a (Fig. 1). isolated from the same source as that of oleanolic acid 1, have also been investigated. (C) 2003 Academie des sciences. Published by editions scientifiques et medicales Elsevier SAS. All rights reserved.