Journal
ASAIO JOURNAL
Volume 57, Issue 1, Pages 26-31Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAT.0b013e3181fcbd86
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Funding
- National Institutes of Health [1R01EB008004-01]
- SBIR [1 R43 HL070401-01A1]
- SBIR phase I
- SBIR phase II [2 R44 HL070401-02]
- Department of Biomedical Engineering at Florida International University, Miami, FL
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R44HL070401, R43HL070401] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB008004] Funding Source: NIH RePORTER
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Trileaflet polymeric prosthetic aortic valves (AVs) produce hemodynamic characteristics akin to the natural AV and may be most suitable for applications such as transcatheter implantation and mechanical circulatory support (MCS) devices. Their success has not yet been realized due to problems of calcification, durability, and thrombosis. We address the latter by comparing the platelet activation rates (PARs) of an improved polymer valve design (Innovia LLC) made from poly(styrene-block-isobutylene-block-styrene) (SIBS) with the commercially available Carpentier-Edwards Perimount Magna Aortic Bioprosthetic Valve. We used our modified prothrombinase platelet activity state (PAS) assay and flow cytometry methods to measure platelet activation of a pair of 19 mm valves mounted inside a pulsatile Berlin left ventricular assist device (LVAD). The PAR of the polymer valve measured with the PAS assay was fivefold lower than that of the tissue valve (p = 0.005) and fourfold lower with flow cytometry measurements (p = 0.007). In vitro hydrodynamic tests showed clinically similar performance of the Innovia and Magna valves. These results demonstrate a significant improvement in thrombogenic performance of the polymer valve compared with our previous study of the former valve design and encourage further development of SIBS for use in heart valve prostheses. ASAIO Journal 2011; 57:26-31.
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