Journal
ASAIO JOURNAL
Volume 56, Issue 6, Pages 563-568Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAT.0b013e3181fcbe24
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Funding
- Academy of Sciences of the Czech Republic [AV0Z50390703, AV0Z50390512]
- Ministry of Education, Youth, and Sports of the Czech Republic [NPV II 2B06130]
- Grant Agency of the Academy of Sciences [IAA500390702]
- Czech Science Foundation [GA202/09/1151, P304/10/1307]
- EU [214539]
- Grant Agency of Charles University [119209]
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Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP). ASAIO Journal 2010; 56:563-568.
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