Journal
NEUROLOGICAL RESEARCH
Volume 25, Issue 3, Pages 249-253Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/016164103101201454
Keywords
Akt; caspase-3; caspase-9; glial cell line-derived neurotrophic factor (GDNF); ischemia; rat
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Neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) on cell survival and death signals were investigated after 90 min of transient middle cerebral artery occlusion (MCAO) in rats. Immunoreactivities of phosphorylated Akt (p-Akt), cleaved caspase-9 (c-cas9), and -3 (c-cas3) increased after the reperfusion in the penumbra in vehicle group with peaks at 3 h, S h, and 1 day, respectively. Topical application of GDNF (6.8 mug/9 mul) on brain surface potentiated and prolonged p-Akt activation, but suppressed activation of the caspases, and reduced the number of terminal deoxynucleotidyl transferase-mediated dUDP-biotin in situ nick labeling (TUNEL) positive cells: These results suggest that GDNF plays a protective role against ischemic injury by controlling the balance between Akt pathway and caspase cascades.
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