Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 8, Pages 5014-5016Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.8.5014-5016.2003
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The absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8(+)-T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.
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