Journal
NATURAL PRODUCT REPORTS
Volume 20, Issue 2, Pages 252-273Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b202149h
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The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.
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