Journal
BIOSTATISTICS
Volume 4, Issue 2, Pages 195-206Publisher
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/4.2.195
Keywords
family-based association tests (FBATs); GEE; genetic association tests; multivariate phenotypes
Funding
- NHLBI NIH HHS [HL66383, N01 HR16040] Funding Source: Medline
- NIMH NIH HHS [MH59532] Funding Source: Medline
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In this paper we propose a multivariate extension of family-based association tests based on generalized estimating equations. The test can be applied to multiple phenotypes and to phenotypic data obtained in longitudinal studies without making any distributional assumptions for the phenotypic observations. Methods for handling missing phenotypic information are discussed. Further, we compare the power of the multivariate test with permutation tests and with using separate tests for each outcome which are adjusted for multiple testing. Application of the proposed test to an asthma study illustrates the power of the approach.
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