Journal
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume 36, Issue 4, Pages 364-366Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004836-200304000-00017
Keywords
crystallization; bile; gallbladder; cholesterol
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Background: Biliary crystal morphology is best described in patients with gallbladder stones, but most patients undergoing bile collection for microscopy have a clinical diagnosis of acalculous gallbladder disease. We investigated the morphology of biliary crystals in such patients. Study: Bile was obtained for polarizing microscopy from fresh cholecystectomy specimens of patients with a clinical diagnosis of acalculous or calculous gallbladder disease. Slides for microscopy were prepared by touch contact with bile in freshly opened gallbladder specimens, and following aspiration of gallbladder bile through a 5-French cannula. Results: Bile was examined from five patients with a clinical diagnosis of acalculous gallbladder disease and five patients with known gallstones, Needle-like cholesterol crystals predominated in most patients without gallstones, whereas plate-like and dot-like crystals were more common in patients with gallstones. All three crystal types were seen in most patients. Crystal morphology was not affected by aspiration of bile through a 5-French cannula. Conclusions: Birefringent needles and dots should be recognized as cholesterol crystals during bile microscopy. These crystal morphologies may predominate in some patients with a clinical diagnosis of acalculous gallbladder disease.
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