Journal
TRENDS IN IMMUNOLOGY
Volume 24, Issue 4, Pages 158-161Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(03)00058-9
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Allergy is a complex inflammatory disease, the etiology of which is well defined. It has recently been proposed that eosinophil, mast-cell and fibroblast interactions contribute to allergy perpetuation. Moreover, mast-cell-derived tryptase might act as a link among these cells. This hypothesis is supported by two recent papers that show that tryptase, seemingly through the protease-activated receptor-2, mediates eosinophil infiltration in the airways and fibroblast proliferation that depends on both cyclooxygenase and prostaglandin synthesis.
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