Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 121, Issue 1, Pages 97-100Publisher
WILEY
DOI: 10.1046/j.1365-2141.2003.04227.x
Keywords
B-CLL; PTEN gene; microsatellite markers; allelic imbalance; loss of heterozygosity; tumour suppressor gene
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One fifth of B-cell chronic lymphocytic leukaemia (B-CLL) patients exhibit loss of heterozygosity (LOH) at 10q23.3, the site of the tumour suppressor PTEN. Microsatellite markers mapped complete LOH to 10q23.3 in 2/41 B-CLL (5%) and allelic imbalances in 6/41 (15%). No PTEN gene mutations were found. PTEN protein expression was not detected in 11 B-CLL (28%), and was reduced in eight patients (20%). LOH or allelic imbalances at 10q23.3 were fairly frequent in B-CLL, but did not encompass the PTEN gene. Nevertheless, PTEN protein may be absent in B-CLL with a normal PTEN genotype, suggesting a role of this phosphatase in the molecular pathology of B-CLL.
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