Journal
RADIOLOGY
Volume 227, Issue 1, Pages 289-294Publisher
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.2271020383
Keywords
kidney, function; kidney, perfusion; magnetic resonance (MR), contrast enhancement; magnetic resonance (MR), perfusion study
Funding
- NIDDK NIH HHS [K23-DK02814] Funding Source: Medline
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A three-dimensional magnetic resonance (MR) renographic method to measure single kidney glomerular filtration rate (GFR) and split renal function was developed that is based on renal signal intensity measurements during 2-3 minutes after intravenous injection of a low dose (2 mL or 0.01 mmol/kg) of gadopentetate dimeglumine. In nine subjects, single kidney MR GFR indices correlated well with technetium (Tc-99m) diethylenetriaminepentaacetic acid (DTPA) clearance (r = 0.7-0.8) for GFR values of 7-48 mL/min. MR right kidney split renal function values (range, 32%-59%) also correlated well with Tc-99m-DTPA radionuclide measurements (r = 0.76); differences between the two methods averaged 0.8% +/- 8. MR renography was performed along with contrast material-enhanced MR imaging of the kidneys and renal arteries and added 8 minutes or less to the total examination time. (C) RSNA, 2003.
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