Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 14, Issue 2, Pages 91-98Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(02)00090-4
Keywords
PDGF; mesenchymal origin; pathophysiological process
Categories
Ask authors/readers for more resources
Platelet-derived growth factors (PDGFs) were discovered almost two decades ago. The classical PDGF polypeptide chains, PDGF-A and PDGF-B, are well studied and they regulate a number of physiological and pathophysiological processes in many types of mesenchymal cells via two receptor tyrosine kinases, PDGF receptors alpha and beta. Recently, two additional PDGF polypeptide chains were discovered, namely PDGF-C and PDGF-D. The discovery of two additional ligands for the two PDGF receptors suggests that PDGF-mediated signaling is more complex than previously anticipated. (C) 2003 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available