Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 47, Issue 4, Pages 1452-1455Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.4.1452-1455.2003
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We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.
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