Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 2, Pages 225-232Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00006-2
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- NICHD NIH HHS [HD 035920] Funding Source: Medline
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The origins of the non-hematopoietic cell types that comprise the thymic stroma remain a topic of considerable controversy. Three recent studies, using lineage analysis and other methods to determine the developmental potential of specific cell types within the thymus, have provided strong evidence of a single endodermal origin for all thymic epithelial cells. Together with other investigations that merge immunological and developmental biology approaches, these studies have suggested a new model of thymus organogenesis, and have begun to uncover the molecular pathways that control this process.
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