Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 14, Issue 2, Pages 127-134Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/S1084-9521(02)00181-7
Keywords
Notch; cell fate; T-cell; T-reg; tolerance
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The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway's role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function. (C) 2003 Elsevier Science Ltd. All rights reserved.
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