Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 187, Issue 7, Pages 1147-1152Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/368380
Keywords
-
Categories
Funding
- NCI NIH HHS [P30 CA 71789, R01 CA 58598, N01 PC 67001, N01 CN 55424] Funding Source: Medline
Ask authors/readers for more resources
Pelvic inflammatory disease has been inconsistently linked with ovarian cancer. We measured antibodies to Chlamydia trachomatis, to chlamydial heat shock protein (CHSP) 60, and to CHSP10, in 117 women with ovarian cancer and in 171 age- and ethnicity-matched population-based control subjects from Oahu, Hawaii. IgG antibodies to serovar D of chlamydia elementary bodies (EB) and IgG antibodies to CHSP60-1, CHSP60-2, CHSP60-3, and CHSP10 were detected using an ELISA assay. The probability of having ovarian cancer was 90% greater in women with the highest, compared with the lowest (optical density, greater than or equal to 0.40 vs. <0.10), levels of chlamydia-EB antibodies (P = .05). There was also a monotonic trend (P = .09) in ovarian cancer risk associated with CHSP60-1 but not with CHSP60-2, CHSP60-3, or CHSP10. These data suggest that past or chronic persistent infection with chlamydia may be a risk factor for ovarian cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available