Journal
MOLECULAR CELL
Volume 11, Issue 4, Pages 905-914Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(03)00102-3
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Funding
- NCI NIH HHS [CA71907, CA42063, CA21765, CA76379] Funding Source: Medline
- NIDDK NIH HHS [DK44158, 1F32 DK10154] Funding Source: Medline
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Myc and E2f1 promote cell cycle progression, but overexpression of either can trigger p53-dependent apoptosis. Mice expressing an Emu-Myc transgene in B lymphocytes develop lymphomas, the majority of which sustain mutations of either the Arf or p53 tumor suppressors. Emu-Myc transgenic mice lacking one or both E2f1 alleles exhibited a slower onset of lymphoma development associated with increased expression of the cyclin-dependent kinase inhibitor p27(Kip1) and a reduced S phase fraction in precancerous B cells. In contrast, Myc-induced apoptosis and the frequency of Arf and p53 mutations in lymphomas were unaffected by E2f1 loss. Therefore, Myc does not require E2f1 to induce Arf, p53, or apoptosis in B cells, but depends upon E2f1 to accelerate cell cycle progression and downregulate p27(Kip1).
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