Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 8, Issue 2, Pages 273-280Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.1559727
Keywords
photoacoustic; thermoelastic; optical diagnostics; optical imaging
Funding
- NCRR NIH HHS [P41-RR-01192] Funding Source: Medline
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We introduce a minimally invasive technique for optoacoustic imaging of turbid media using optical interferometric detection of surface displacement produced by thermoelastic stress transients. The technique exploits endogenous or exogenous optical contrast of heterogeneous tissues and the low attenuation of stress wave propagation to localize and image subsurface absorbers in optically turbid media. We present a system that utilizes a time-resolved high-resolution interferometer capable of angstrom-level displacement resolution and nanosecond temporal resolution to detect subsurface blood vessels within model tissue phantoms and a human forearm in vivo. (C) 2003 Society of Photo-Optical Instrumentation Engineers.
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