Journal
DRUG DELIVERY
Volume 10, Issue 2, Pages 95-100Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/713840365
Keywords
antitumor activity; K562 cells; lipoamino acids; lipophilic conjugates; liposomes; methotrexate
Categories
Ask authors/readers for more resources
Some selected lipophilic conjugates of the antifolate drug methotrexate (MTX) with lipoamino acids (LAA), previously described, were incorporated in liposomes with a different composition and charge ( neutral, positive, or negative). The properties of the liposomal systems were determined. The inhibitory activity of the conjugates after incorporation in the vesicles was determined in a preliminary assessment against a human erythroleukemic cell line (K562 cells) and compared with the activity of the parent drug and of free conjugates. The influence of liposome surface charge and of the type of conjugate (i.e., in the carboxylic or ester form) on the biological effect is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available