Journal
JOURNAL OF SURFACTANTS AND DETERGENTS
Volume 6, Issue 2, Pages 119-123Publisher
WILEY
DOI: 10.1007/s11743-003-0254-5
Keywords
antielectrostatic effect; antimicrobial activity; pyridinium chlorides
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Several 1-alkoxymethyl-3-substituted-pyridinium chlorides with alkoxy chains including from 3 to 18 carbon atoms were prepared by the reaction of 3-substituted-pyridine with chloromethyl alkyl ethers. The prepared chlorides were examined for their antielectrostatic effects and their antimicrobial activities. 1-Dodecyloxymethyl-3-dimethylaminopyridinium chloride (23) exhibited strong antimicrobial activity and a wide antimicrobial spectrum, similar to the activity of benzalkonium chloride. We synthesized 1-alkoxymethyl-3-hydroxypyridinium chlorides possessing antielectrostatic properties, but lacking antimicrobial activity. The antielectrostatic effect and antimicrobial activities are strongly dependent on the kind of substituent at the 3-position in the pyridine ring and are greatly affected by an alkoxy chain. It was shown that dimethylamino group in position three must be present for a high antielectrostatic and antimicrobial activity of the agent.
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