Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 345, Issue 4, Pages 533-536Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200390062
Keywords
alpha-arylation; ketones; ligand-free homogeneous catalysis; palladium; pinacolone
Categories
Ask authors/readers for more resources
An efficient and large-scale synthesis of I(4-chlorophenyl)-3,3-dimethyl-2-butanone (1) by an alpha-arylation of pinacolone (2) with 1-bromo-4-chlorobenzene (3) in the presence of palladium acetate and sodium t-butoxide in toluene is described. An increase in the concentration of sodium t-butoxide to 2.5 - 3.0 equivalents suppressed the formation of over-arylated products. These ligand-free conditions afforded a yield of 1 that was comparable to those obtained by using a ligand.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available