Journal
TRENDS IN IMMUNOLOGY
Volume 24, Issue 4, Pages 155-158Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(03)00062-0
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Three members of the S100 family of calcium-binding proteins comprise a new group of proinflarnmatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.
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