Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 7, Pages 3528-3533Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.7.3528
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Funding
- NCI NIH HHS [CA88053] Funding Source: Medline
- NICHD NIH HHS [HD38764] Funding Source: Medline
- NIDDK NIH HHS [R01 DK56597] Funding Source: Medline
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Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t(1/2) compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC. class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions. To understand the phenotypes imposed by FcRn, we produced and analyzed mice with a defective FcRn gene. The results provide direct evidence that perinatal IgG transport and protection of IgG from catabolism are mediated by FCRn, and that the latter function is key to IgG homeostasis, essential for generating a potent IgG response to foreign Ags, and the basis of enhanced efficacy of Fc-IgG-based therapeutics. FcRn is therefore a promising therapeutic target for enhancing protective Immoral immunity, treating, autoimmune disease, and improving drug efficacy.
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