Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 7, Pages 1199-1207Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00298
Keywords
ZP proteins; cuticulin envelope; epithelial morphogenesis; cuticule formation; Drosophila
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We have characterised the function of two Drosophila genes, miniature and dusky, that are required for the morphological reorganisation of the apical membrane during wing epidermis differentiation. These genes encode transmembrane proteins containing a ZP (zona pellucida) domain and are homologous to several vertebrate and invertebrate apical matrix components. miniature and dusky are only expressed in tissues secreting a cuticle, and the Min protein localises to the apical membrane during the early stages of cuticle formation. We propose that Min and Dusky form a novel subfamily within the ZP domain proteins and are specifically involved in the interactions between the apical membrane, the cytoskeleton and the forming cuticle.
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