Journal
NATURE REVIEWS IMMUNOLOGY
Volume 3, Issue 4, Pages 269-279Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1052
Keywords
-
Categories
Ask authors/readers for more resources
Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8(+) T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family - in particular, interleukin-7 (IL-7) and IL-15 - act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8(+) T-cell pool can be propagated and maintained.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available