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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

Journal

CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 7, Issue 2, Pages 285-295

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(03)00020-6

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Funding

  1. NCI NIH HHS [CA78747] Funding Source: Medline
  2. NIAID NIH HHS [AI51689] Funding Source: Medline

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Recent literature on polyketide biosynthesis suggests that polyketide synthases have much greater diversity in both mechanism and structure than the current type I, II and III paradigms. These examples serve as an inspiration for searching novel polyketide synthases to give new insights into polyketide biosynthesis and to provide new opportunities for combinatorial biosynthesis.

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