Journal
JOURNAL OF NEUROVIROLOGY
Volume 9, Issue 2, Pages 236-246Publisher
SPRINGER
DOI: 10.1080/13550280390194019
Keywords
demyelination; human polyomavirus; JC infection; PML therapy; viral pathogenesis
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Since the initial description of progressive multifocal leukoencephalopathy (PML) in 1958, clinical and basic science investigators have demonstrated a growing interest in the area of neurovirology, with a recent focus on polyomaviruses. In this review, the authors present an overview of the biological properties of the human polyomavirus, JC virus (JCV), and its association with PML as the etiologic agent. Additionally, the authors provide a discussion of the current understanding of JCV molecular pathogenesis and therapeutic strategies.
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