Journal
VISION RESEARCH
Volume 43, Issue 8, Pages 867-877Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(02)00594-1
Keywords
bipolar cell; dendritic atrophy; horizontal cells; ERG; retinitis pigmentosa
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Funding
- NEI NIH HHS [R01EY12654] Funding Source: Medline
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This is a brief review of data obtained by analyzing the morphology and the physiology of the retinas in rd/rd and normal, wt mice, aged 10-90 days. Second-order neurons of the rd/rd show abnormalities that start with the anomalous development of rod bipolar cells around P10 and culminate with the atrophy of dendrites in cone bipolar cells, mostly evident at P90. Horizontal cells remodel considerably. Cone-mediated ERGs, (recorded between 13 and 16 days of age) have reduced a-wave and b-wave amplitudes and longer b-wave latency and duration. B-wave abnormalities indicate specific postreceptoral dysfunction. Morphological and ERG changes in rd/rd retinas are consistent with substantial inner retinal remodeling associated to photoreceptor degeneration. (C) 2003 Elsevier Science Ltd. All rights reserved.
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