Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 8, Pages 4985-4991Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.8.4985-4991.2003
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Funding
- NIAID NIH HHS [R01 AI047770, R01 AI052051, R01 AI47770, R21 AI052051] Funding Source: Medline
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The events preceding human immunodeficiency virus fusion and entry are influenced by the concentration and distribution of receptor and coreceptor molecules on the cell surface. However, the extent to which these proteins colocalize with one another in the cell membrane remains unclear. Using high-resolution deconvolution fluorescent microscopy of living cells, we found that both CD4 and CCR5 accumulate in protruding membrane structures containing actin and ezrin. Although CD4 and CCR5 extensively colocalize in these structures, they do not exist in a stable complex.
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