Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 51, Issue 4, Pages 545-548Publisher
HISTOCHEMICAL SOC INC
DOI: 10.1177/002215540305100417
Keywords
Russell bodies; aggresomes; ER; CFTR; BiP; chaperone; yeast; ERAD
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Funding
- NIDDK NIH HHS [DK60385-01] Funding Source: Medline
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Almost all secreted proteins pass through the endoplasmic reticulum (ER), an organelle that is equipped to tolerate and/or degrade misfolded proteins. We report here that yeast expressing the cystic fibrosis transmembrane conductance regulator (CFTR) concentrate the protein at defined sites in the ER membrane that are not necessarily enriched for the ER molecular chaperone BiP. We propose that these sites are Russell bodies, an ER subcompartment in which misfolded proteins are stored and can be targeted for degradation.
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