Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 111, Issue 8, Pages 1125-1132Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200317170
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Funding
- NINDS NIH HHS [P50 NS010828, 5P50 NS 10828] Funding Source: Medline
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EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-Iabeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair.
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