Journal
CARDIOVASCULAR RESEARCH
Volume 58, Issue 1, Pages 20-31Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0008-6363(02)00852-0
Keywords
angiogenesis; growth factors; receptors; sequence (DNA/RNA/prot)
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Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder in humans which has been mapped to two genes, endoglin and activin receptor-like kinase-1 (ALK-1) both of which mediate signaling by transforming growth factor ligands in vascular endothelial cells. Animal models have shown that these receptors are not only important for maintaining vascular integrity but also for angiogenesis both during embryonic development and during tumor growth. Here, we review the current status of reported mutations in the context of the clinical manifestations and the effects on the vessel wall both in patients and in animal models of the disease. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.
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