Journal
IMMUNITY
Volume 18, Issue 4, Pages 549-559Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(03)00087-6
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Funding
- NCI NIH HHS [CA21765] Funding Source: Medline
- NIAID NIH HHS [AI29579] Funding Source: Medline
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The spectrum of TCR Vbeta usage is compared for primary and recall CD8(+)D(b)PA(224)(+) T cell responses in mice with influenza pneumonia. Single-cell RT-PCR established that the same clonotypes were present in the lymphoid tissue and in the virus-infected lung. Longitudinal analysis indicated that the memory TCR repertoire reflects the primary response, with no decrease in diversity prior to (or after) secondary challenge. The re-engagement of memory T cells looked to be stochastic in this localized, transient infection. Analysis of clonotypes from the blood, spleen, regional lymph nodes, bone marrow, lung, and liver over a 200 day interval showed no evidence of selective localization or loss. The long-term distribution of memory T cells seemed to be essentially random.
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