Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 31, Issue 5, Pages 885-891Publisher
ELSEVIER
DOI: 10.1016/S0731-7085(02)00670-2
Keywords
space environmental effect; atropine and scopolamine; Datura metel; capillary zone electrophoresis
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The seeds of Datura metel were carried aboard a retrievable satellite and exposed to space environment, The effects of space environment (weightlessness and ionizing radiation) on the contents of atropine and scopolamine in D. metel were investigated by using an effective capillary zone electrophoresis (CZE) method. which emploed 50 mmol/l phosphate buffer (pH 8) containing 10%, (v/v) tetrahydrofuran as the running buffer. The results showed that tile contents of atropine and scopolamine varied to some extent. and the earth-control group has the lowest content of atropine. However, the variation of atropine and scopolamine contents in three groups was not obvious based on t-test. At the same time, the optimization of the separation as discussed in detail and the two compounds were completely separated within 10 min with satisfactory repeatability and calibration linearity. (C) 2003 Elsevier Science B.V. All rights reserved.
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