Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 13, Issue 2, Pages 227-235Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(03)00039-3
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Funding
- NIAMS NIH HHS [AR45990] Funding Source: Medline
- PHS HHS [57407, 30954] Funding Source: Medline
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Experiments in which two specifically interacting protein molecules are dissociated by external force have yielded new insights into mechanisms involved in cell adhesion, leukocyte rolling, regulation of integrin activity, antigen-antibody interactions and other protein-mediated reactions contingent upon molecular recognition. Another important aspect of force-induced protein-protein unbinding studies is the new information being gleaned about the thermodynamics and kinetics of bond rupture.
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