Journal
BIOSTATISTICS
Volume 4, Issue 2, Pages 223-229Publisher
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/4.2.223
Keywords
combining tests; link-age analysis; random effects models; tests for association
Funding
- NIGMS NIH HHS [GM31575] Funding Source: Medline
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A robust statistical method to detect linkage or association between a genetic marker and a set of distinct phenotypic traits is to combine univariate trait-specific test statistics for a more powerful overall test. This procedure does not need complex modeling assumptions, can easily handle the problem with partially missing trait values, and is applicable to the case with a mixture of qualitative and quantitative traits. In this note, we propose a simple test procedure along this line, and show its advantages over the standard combination tests for linkage or association in the literature through a data set from Genetic Analysis Work-shop 12 (GAW12) and an extensive simulation study.
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