Journal
PHYTOTHERAPY RESEARCH
Volume 17, Issue 4, Pages 341-344Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.1140
Keywords
Bombax ceiba; lupeol; antiangiogenic activity; cytotoxicity
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In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 mug/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma. Copyright (C) 2003 John Wiley Sons, Ltd.
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