4.8 Article

Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base

Journal

ORGANIC LETTERS
Volume 5, Issue 7, Pages 1155-1158

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol034286z

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Funding

  1. NCI NIH HHS [U19CA52995] Funding Source: Medline
  2. NIGMS NIH HHS [GM66509] Funding Source: Medline

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[GRAPHIC] Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

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