Journal
JOURNAL OF CELL BIOLOGY
Volume 161, Issue 1, Pages 169-186Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200210110
Keywords
stem cell; oligodendrocyte progenitor; differentiation; adult neurogenesis; glia
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Funding
- NICHD NIH HHS [P30 HD040677, P30HD40677] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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Neurogenesis is known to persist in the adult mammalian central nervous system (CNS). The identity of the cells that generate new neurons in the postnatal CNS has become a crucial but elusive issue. Using a transgenic mouse, we show that NG2 proteoglycan-positive progenitor cells that express the 2',3'-cyclic nucleoticle 3'-phosphodiesterase gene display a multipotent phenotype in vitro and generate electrically excitable neurons, as well as astrocytes and oligodendrocytes. The fast kinetics and the high rate of multipotent fate of these NG2(+) progenitors in vitro reflect an intrinsic property rather than reprogramming. We demonstrate in the hippocampus in vivo that a sizeable fraction of postnatal NG2(+) progenitor cells are proliferative precursors whose progeny appears to differentiate into GABAergic neurons capable of propagating action potentials and displaying functional synaptic inputs. These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis.
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