Journal
BLOOD
Volume 101, Issue 8, Pages 3052-3057Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2002-09-2876
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Funding
- NCI NIH HHS [P30CA16058, CA65670, CA68458] Funding Source: Medline
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Natural killer (NK) cells are innate lymphocytes that provide cytokines critical. for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, We demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole.. (C) 2003 by The American Society of Hematology.
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