Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 8, Pages 4849-4854Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0734299100
Keywords
gap junction; Mauthner; postsynaptic density (PSD); plasticity; long-term potentiation; long-term depression
Categories
Funding
- NIDCD NIH HHS [R01 DC003186, R29 DC003186, DC03186, R56 DC003186] Funding Source: Medline
- NINDS NIH HHS [R01 NS015335, NS15335] Funding Source: Medline
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Most electrically coupled neurons also receive numerous chemical synaptic inputs. Whereas chemical synapses are known to be highly dynamic, gap junction-mediated electrical transmission often is considered to be less modifiable and variable. By using simultaneous pre- and postsynaptic recordings, we demonstrate at single mixed electrical and chemical synapses that fast chemical transmission interacts with gap junctions within the same ending to regulate their conductance. Such localized interaction is activity-dependent and could account for the large variation in strength of electrical coupling at auditory afferent synapses terminating on the Mauthner cell lateral dendrite. Thus, interactions between chemical and electrical synapses can regulate the degree of electrical coupling, making it possible for a given neuron to independently modify coupling at different electrical synapses with its neighbors.
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