Journal
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
Volume 40, Issue 5, Pages 345-353Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10731199.2012.675337
Keywords
Multiphase hydrogel; wound healing; serratiopeptidase; gentamicin; microspheres; moist healing
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A biocompatible moist system was developed for effective and complete wound healing. Optimized PLGA microspheres of gentamicin (GM) and serratiopeptidase (STP) were incorporated into PVA-gelatin slurry and casted into films to prepare multiphase hydrogel. The prepared system was characterized by in vitro and in vivo studies. Results revealed the uniform dispersion of microspheres in three-dimensional matrix of the hydrogel. The in vitro release data showed a typical biphasic release pattern. All parameters such as wound contraction, tensile strength, histopathological and biochemical parameters were observed significant (p < 0.05) in comparison to the control group. Results suggested an accelerated re-epithelialization with minimum disturbance of wound bed.
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