Journal
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
Volume 40, Issue 1-2, Pages 113-119Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10731199.2011.597759
Keywords
Oleoyl alginate ester nanoparticles; Vitamin D-3; Caco-2 cells; rickets
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Funding
- high-tech research and development plan (863 plan) of China [2007AA10Z349]
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We report the application of Vitamin D-3 (VD3) in nanoparticles of oleoyl alginate ester (OAE) (OAE-VD3). The internalization of fluorescent OAE-VD3 by Caco-2 cells was visualized by confocal laser scanning microscopy. In vivo pharmacokinetic studies showed that incorporation into OAE nanoparticles resulted in increased absorption of VD3. Its application in the treatment of rickets was assayed using a model of nutritionally induced vitamin D-deficiency rickets. The results showed that the encapsulated VD3 had better efficacy than that of the free drug in vivo. Our studies provide evidence that OAE nanoparticles are valuable as nutraceutical delivery vehicles to enhance the absorption of VD(3).
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