Journal
ONCOGENE
Volume 22, Issue 15, Pages 2361-2373Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1206344
Keywords
glioblastoma; EGFR; microarray; 12q13-15
Funding
- NCI NIH HHS [T32 CA 09056, U01 CA88127] Funding Source: Medline
- NINDS NIH HHS [K08NS43147-01] Funding Source: Medline
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Epidermal growth factor receptor (EGFR) overexpression occurs in nearly 50% of cases of glioblastoma (GBM), but its clinical and biological implications are not well understood. We have used Affymetrix high-density oligonucleotide arrays to demonstrate that EGFR-over-expressing GBMs (EGFR +) have a distinct global gene transcriptional profile. We show that the expression of 90 genes can distinguish EGFR + from EGFR nonexpressing (EGFR-) GBMs, including a number of genes known to act as growth/survival factors for GBMs. We have also uncovered two additional novel molecular subtypes of GBMs, one of which is characterized by coordinate upregulation of contiguous genes on chromosome 12q13-15 and expression of both astrocytic and oligodendroglial genes. These results define distinct molecular subtypes of GBMs that may be important in disease stratification, and in the discovery and assessment of GBM treatment strategies.
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