4.8 Article

Novel synthetic approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene skeleton

Journal

ORGANIC LETTERS
Volume 5, Issue 8, Pages 1289-1292

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol034213f

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Funding

  1. NCI NIH HHS [CA-28824] Funding Source: Medline

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An efficient and highly stereocontrolled approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene carbon skeleton starting with the Wieland-Miescher ketone is described. The approach centers on a Diels-Alder-angular methylation-deoxygenation sequence.

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