Journal
SCIENCE
Volume 300, Issue 5618, Pages 486-489Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1079469
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Funding
- NIA NIH HHS [AG00538, AG16573] Funding Source: Medline
- NINDS NIH HHS [NS31230] Funding Source: Medline
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Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Abeta peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.
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