Journal
TETRAHEDRON LETTERS
Volume 44, Issue 17, Pages 3471-3475Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00671-3
Keywords
alkaloid; Didemnum; fascaplysin; Fascaplysinopsis; sponge; tunicate
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The structural variations and bioactivity properties of the alkaloids in the fascaplysin (1) and the reticulatine (3) families were examined. Four organisms were analyzed consisting of two collections of the sponge Fascaplysinopsis reticulata and two collections of the tunicate Didemnum sp. Reported are the isolation of three new compounds: 3-bromofascaplysin (2), 14-bromoreticulatine (4), and 14-bromoreticulatate (6) along with reticulatate (5) previously known as a semi-synthetic product of 1. Compounds I and 5 showed selectivity in a cell based cytotoxicity assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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